D. W. Gerlich

PP2A-B55alpha,delta phosphatase counteracts Ki67-dependent chromosome individualization during mitosis

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase

This study shows cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase, independent of condensins, suggesting loop extrusion is a general mechanism for genome segregation.

Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

This study shows cohesin uses distinct mechanisms for DNA loop extrusion and sister chromatid cohesion, and that CTCF boundary interactions may rely on related mechanisms.

In Diverse Conditions Intrinsic Chromatin Condensates Have Liquid-like Material Properties

This study shows that intrinsic chromatin condensates exhibit liquid-like properties under diverse conditions, challenging previous claims of their solidity.

A chromatin phase transition protects mitotic chromosomes against microtubule perforation

This study shows that global histone deacetylation during mitosis induces a chromatin phase transition that protects chromosomes from microtubule perforation and ensures proper segregation.

u-track 3D: measuring and interrogating dense particle dynamics in three dimensions.

u-track 3D provides a software package for analyzing dense 3D particle dynamics in microscopy data by improving visualization, trajectory validation, and interactive exploration.

Sister-chromatid-sensitive Hi-C reveals the conformation of replicated human chromosomes

This study introduces scsHi-C to analyze sister-chromatid interactions in human chromosomes, revealing frequent contacts at TAD boundaries and dynamic cohesin roles.

Augmin-mediated amplification of long-lived spindle microtubules directs plus-ends to kinetochores

The paper shows that Augmin amplifies long-lived microtubules, directing their plus-ends to kinetochores during spindle assembly in human cells.

Dynamics of sister chromatid resolution during cell cycle progression

This study investigates sister chromatid organization in live human cells, finding that sister loci separate during G2 phase and equilibrate within dynamic chromatin polymers, challenging the notion of persistent cohesin sites.

A Deep Learning And Novelty Detection Framework For Rapid Phenotyping In High-Content Screening

CellCognition Explorer uses deep learning and novelty detection to rapidly phenotype high-content screening data without prior phenotype knowledge or user training.

PARP inhibition causes premature loss of cohesion in cancer cells

This study shows PARP inhibition causes premature cohesion loss in cancer cells during mitosis, leading to sister chromatid scattering, and identifies PARP1/2 entrapment at replication forks as a mechanism.