Author

L. Karydis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. J. Steele· 2 shared F. Forconi· 2 shared A. D'Avola· 1 shared A. J. Linley· 1 shared A. Mondru· 1 shared A. R. Pettitt· 1 shared A. Rawstron· 1 shared A. Russell· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. J. Steele

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2 papers

Recent·Most cited

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

D. Bryant, L. Smith, K. R. Rogers-Broadway, L. Karydis, J. Woo, M. D. Blunt, F. Forconi, F. K. Stevenson, C. Goodnow, P. Humberg, A. Russell, G. K. Packham, A. J. Steele, J. C. Strefford

The paper identifies 14q32 cluster miRNAs as key regulators of transcriptional differences between IGHV-mutated and unmutated CLL, with miR-409-3p and miR-411-3p repressing GAB1.

bioRxiv · Apr 26, 2022Cancer Biology

Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells.

A. J. Linley, L. Karydis, A. Mondru, A. D'Avola, S. Cicconi, R. Griffin, F. Forconi, A. R. Pettitt, N. Kalakonda, A. Rawstron, P. Hillmen, A. J. Steele, D. J. MacEwan, G. Packham, I. Prior, J. Slupsky

This study uses kinobead profiling and mass spectrometry to analyze B-cell receptor signaling changes in CLL cells before and after therapy, revealing adaptive reprogramming in response to treatment.

bioRxiv · Jun 4, 2020Cancer Biology