Author

P. Hillmen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bridgeman· 1 shared A. Chabes· 1 shared A. D'Avola· 1 shared A. J. Linley· 1 shared A. J. Steele· 1 shared A. Mondru· 1 shared A. R. Pettitt· 1 shared A. Rawstron· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bridgeman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients

D. J. Payne, S. Dalal, R. Leach, R. Parker, S. Griffin, C. S. McKimmie, G. P. Cook, S. J. Richards, P. Hillmen, T. Munir, L. Arnold, K. Riley, C. McKinley, S. Place, R. L. Baretto, D. J. Newton

This study examines the role of the CXCR6/CXCL16 axis in severe COVID-19, finding elevated CD8+CXCR6+ T cells with age and increased CXCL16 levels in severe cases.

bioRxiv · Jan 25, 2021 · PreprintImmunology

Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells.

A. J. Linley, L. Karydis, A. Mondru, A. D'Avola, S. Cicconi, R. Griffin, F. Forconi, A. R. Pettitt, N. Kalakonda, A. Rawstron, P. Hillmen, A. J. Steele, D. J. MacEwan, G. Packham, I. Prior, J. Slupsky

This study uses kinobead profiling and mass spectrometry to analyze B-cell receptor signaling changes in CLL cells before and after therapy, revealing adaptive reprogramming in response to treatment.

bioRxiv · Jun 4, 2020Cancer Biology

SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP

T. Davenne, J. Klintman, S. Sharma, R. E. Rigby, C. Cursi, A. Bridgeman, B. Dadonaite, K. De Keersmaecker, P. Hillmen, A. Chabes, A. Schuh, J. Rehwinkel

This paper shows that SAMHD1 protects cells from dGTP toxicity caused by forodesine, and that forodesine can selectively kill SAMHD1-deficient leukemia cells.

bioRxiv · Feb 17, 2020Cancer Biology