Author

L. Kirk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. P. Ragsdale· 1 shared B. Trindade· 1 shared D. M. Aronoff· 1 shared D. Maseda· 1 shared E. P. Skaar· 1 shared G. Vedantam· 1 shared J. G. Schraiber· 1 shared J. L. Roxas· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperEvolutionary Biology

A. P. Ragsdale

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2 papers

Recent·Most cited

A path integral approach for allele frequency dynamics under polygenic selection

N. W. Anderson, L. Kirk, J. G. Schraiber, A. P. Ragsdale

This paper extends a path integral method to polygenic selection scenarios, deriving analytic expressions for allele frequency transitions under stabilizing and adaptive selection to improve evolve-and-resequence experiments.

bioRxiv · Jun 14, 2024Evolutionary Biology

Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response

D. Maseda, J. P. Zackular, B. Trindade, L. Kirk, L. J. Crofford, P. D. Schloss, J. L. Roxas, V. K. Viswanathan, G. Vedantam, L. M. Rogers, M. K. Washington, E. P. Skaar, D. M. Aronoff

This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.

bioRxiv · Aug 14, 2018Microbiology