Author

E. P. Skaar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11 Biochemistry· 2 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:host-pathogen & immune response· 12 Organism:bacteria (other)· 6 Organism:mouse· 6 Assay:proteomics· 6 Organism:human· 5 Research Focus:drug response / drug discovery· 3 Approach:genetic perturbation / CRISPR· 3

Frequent Co-Authors

W. N. Beavers· 3 shared J. M. Spraggins· 2 shared R. M. Caprioli· 2 shared W. J. Chazin· 2 shared A. Anaya-Sanchez· 1 shared A. Dhabaria· 1 shared A. E. Sewell· 1 shared A. Espaillat· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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3 shared papersMicrobiology

W. N. Beavers

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

Restriction of Arginine Induces Antibiotic Tolerance in Staphylococcus aureus

J. A. Freiberg, V. M. R. Ruiz, E. R. Green, E. P. Skaar

This study shows that restricting arginine in Staphylococcus aureus induces antibiotic tolerance, particularly in biofilms, by inhibiting protein synthesis.

bioRxiv · Oct 12, 2023 · PreprintMicrobiology

YlaN is an iron(II) binding protein that functions to relieve Fur-mediated repression of gene expression in Staphylococcus aureus

J. M. Boyd, K. M. esquilin-lebron, C. J. Campbell, K. M. Ryan Kaler, J. Norambuena, M. E. Foley, T. G. Stephens, G. Rios, G. Mereddy, V. Zheng, H. Bovermann, J. Kim, A. W. Kulczyk, J. H. Yang, T. M. Greco, , T. L. Stemmler

This study identifies YlaN as an Fe(II) binding protein in S. aureus that relieves Fur-mediated repression of gene expression during Fe deprivation.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection

L. Spiga, R. T. Fansler, Y. R. Perera, N. G. Shealy, M. J. Munneke, T. P. Torres, H. David, A. Lemoff, X. Ran, K. L. Richardson, N. Pudlo, E. C. Martens, Z. J. Yang, E. P. Skaar, M. X. Byndloss, , W. Zhu

This study shows that the commensal bacterium Bacteroides thetaiotaomicron acquires iron using siderophores from Salmonella, evading host sequestration by lipocalin-2 and allowing Salmonella to bypass nutritional immunity.

bioRxiv · Jun 25, 2023 · PreprintMicrobiology

Differences in self-reported benefits for student-artist versus faculty experiences in a virtual artist-in-residence program.

S. Cuevas, Q. Liu, H. Qian, M. E. Joffe, K. Calvitti, M. Schladt, E. P. Skaar, K. H. Oliver

The paper analyzes survey data from a virtual artist-in-residence program to compare experiences and outcomes between student-artists and faculty, identifying areas for improvement and benefits.

bioRxiv · Sep 14, 2022 · PreprintScientific Communication & Education

Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

K. Voss, A. Young, K. N. Gibson-Corley, A. E. Sewell, E. Krystofiak, J. H. Bashum, W. N. Beavers, A. Sugiura, E. P. Skaar, M. J. Ormseth, J. Rathmell

This study shows that dysregulated CD71 in T cells increases iron uptake, disrupts mitochondrial function, and drives inflammation in SLE, with CD71 blockade improving outcomes.

bioRxiv · Nov 25, 2021 · PreprintImmunology

Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis

R. Rivera-Lugo, D. Deng, A. Anaya-Sanchez, S. Tejedor-Sanz, V. M. Reyes Ruiz, H. B. Smith, D. V. Titov, J. D. Sauer, E. P. Skaar, C. M. Ajo-Franklin, D. A. Portnoy, S. H. Light

This study shows that Listeria monocytogenes uses cellular respiration for NAD+ regeneration, which is critical for its pathogenesis and survival in host cells.

bioRxiv · Nov 25, 2021Microbiology

Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content Shows Molecular Localization Patterns

E. R. Guiberson, A. G. Wexler, C. J. Good, E. P. Skaar, J. M. Spraggins, R. M. Caprioli

This study uses multimodal imaging mass spectrometry to analyze murine gastrointestinal tract tissue and luminal content, revealing distinct molecular patterns during Clostridioides difficile infection.

bioRxiv · Oct 3, 2021Biochemistry

The zinc transporter ZnuABC is critical for the virulence of Chromobacterium violaceum and contributes to diverse zinc-dependent physiological processes

R. E. R. S. Santos, W. P. da Silva Junior, S. A. Harrison, E. P. Skaar, W. J. Chazin, J. F. da Silva Neto

bioRxiv · Jun 3, 2021Microbiology

Spatially-targeted proteomics of the host-pathogen interface during staphylococcal abscess formation

E. Guiberson, A. Weiss, D. J. Ryan, A. J. Monteith, K. Sharman, D. B. Gutierrez, W. J. Perry, R. M. Caprioli, E. P. Skaar, J. M. Spraggins

The paper uses spatially targeted proteomics to analyze host-pathogen interactions during staphylococcal abscess formation, identifying immune responses and bacterial contributions across different abscess regions.

bioRxiv · Sep 1, 2020Microbiology

Directed evolution reveals the mechanism of HitRS signal transduction in Bacillus anthracis

E. P. Skaar, H. Pi, M. Chu, S. Ivan, C. Latario, A. Toth, S. Carlin, G. Hillebrand, H. Lin, J. Reppart, D. L. Stauff

This study uses genetic selections to uncover the molecular mechanism of the HitRS signal transduction system in Bacillus anthracis, identifying key residues and interactions essential for TCS function.

bioRxiv · Jul 3, 2020Biochemistry

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

N.-H. Le, K. Peters, A. Espaillat, J. R. Sheldon, J. Gray, G. Di Venanzio, J. Lopez, B. Djahanschiri, E. A. Mueller, S. W. Hennon, P. A. Levin, I. Ebersberger, E. P. Skaar, F. Cava, W. Vollmer, M. F. Feldman

Acinetobacter baumannii incorporates D-Lysine into its peptidoglycan to gain immunity against T6SS attacks from competitors, though this trait is lost in pathogenic strains due to host enzyme activity.

bioRxiv · Apr 23, 2020Microbiology

Mycobacterium tuberculosis Rv0991c is a redox-regulated molecular chaperone

S. H. Becker, K. Ulrich, A. Dhabaria, B. Ueberheide, W. N. Beavers, E. P. Skaar, L. M. Iyer, L. Aravind, U. Jakob, K. H. Darwin

This paper identifies Rv0991c in M. tuberculosis as a redox-regulated molecular chaperone essential for virulence, functioning similarly to Hsp33 in E. coli.

bioRxiv · Mar 5, 2020Microbiology

Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response

D. Maseda, J. P. Zackular, B. Trindade, L. Kirk, L. J. Crofford, P. D. Schloss, J. L. Roxas, V. K. Viswanathan, G. Vedantam, L. M. Rogers, M. K. Washington, E. P. Skaar, D. M. Aronoff

This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.

bioRxiv · Aug 14, 2018Microbiology

Molecular basis for the evolution of species-specific hemoglobin capture by pathogenic Staphylococcus

J. E. Choby, H. B. Buechi, A. J. Farrand, E. P. Skaar, M. F. Barber

The paper shows that hemoglobin evolution in primates affects bacterial iron acquisition by Staphylococcus aureus, with adaptive mutations impairing bacterial binding.

bioRxiv · Jun 7, 2018Microbiology

Amycomicin: a potent and specific antibiotic discovered with a targeted interaction screen

G. Pishchany, E. Mevers, S. Ndousse-Fetter, D. J. Horvath, C. R. Paludo, E. A. Silva-Junior, S. Koren, E. P. Skaar, J. Clardy, R. Kolter

This paper discovers a new antibiotic, amycomicin, through a community-based screening approach targeting Staphylococcus aureus.

bioRxiv · May 8, 2018Microbiology