Author

M. K. Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 3 Cell Biology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 10 Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

F. Revetta· 4 shared B. Chen· 3 shared D. B. Lacy· 3 shared Q. Liu· 3 shared A. J. Simmons· 2 shared A. N. Southard-Smith· 2 shared J. A. Shupe· 2 shared J. Jacobse· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCancer Biology

F. Revetta

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Author profile →

11 papers

Recent·Most cited

Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

C. R. Detres Roman, M. W. Rudloff, F. Revetta, N. R. Favret, K. A. Murray, J. J. Roetman, M. M. Erwin, M. K. Washington, M. Philip

This study shows vaccination generates functional progenitor tumor-specific CD8 T cells and halts liver cancer progression in a mouse model, while immune checkpoint blockade does not.

bioRxiv · Feb 26, 2024Cancer Biology

Paeniclostridium sordellii NanS works synergistically with TcsL to increase cytotoxicity and the severity of pathogenesis in the murine uterus

S. C. Bernard, H. Kroh, M. K. Washington, D. B. Lacy

This study shows that NanS and TcsL work together to increase cytotoxicity and disease severity in a mouse uterine infection model.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

Eosinophils exert direct and indirect anti-tumorigenic effects in the development of esophageal squamous cell carcinoma

J. Jacobse, Z. Aziz, L. Sun, J. Chaparro, J. M. Pilat, A. Kwag, M. Buendia, M. Wimbiscus, M. Nasu, T. Saito, S. Mine, H. Orita, F. Revetta, S. Short, M. K. Washington, , Y. A. Choksi

This study shows eosinophils reduce esophageal squamous cell carcinoma by releasing reactive oxygen species and inhibiting IL-17 pathways.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

SMAD4 suppresses colitis-associated carcinoma through inhibition of CCL20/CCR6-mediated inflammation

D. N. Hanna, P. Marincola-Smith, S. V. Novitskiy, M. K. Washington, J. Zi, C. J. Weaver, J. A. Hamaamen, K. B. Lewis, J. Zhu, J. Yang, Q. Liu, R. D. Beauchamp, A. L. Means

This study shows that SMAD4 suppresses colitis-associated colon cancer by inhibiting CCL20/CCR6-mediated inflammation in mice.

bioRxiv · May 25, 2022Cancer Biology

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection

F. C. Peritore-Galve, J. A. Shupe, R. J. Cave, M. K. Washington, S. A. Kuehne, D. B. Lacy

This study investigates the role of glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins TcdA and TcdB during infection, showing both contribute to disease with distinct pathological outcomes.

PLOS Pathogens · Feb 17, 2022Peer-reviewedPathology

MTG16 (CBFA2T3) regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors

R. E. Brown, J. Jacobse, S. A. Anant, K. M. Blunt, B. Chen, P. N. Vega, C. T. Jones, J. M. Pilat, F. Revetta, A. H. Gorby, K. R. Stengel, Y. A. Choksi, K. Palin, M. B. Piazuelo, M. K. Washington, , C. S. Williams

This study shows MTG16 regulates colonic epithelial differentiation and tumorigenesis by repressing E protein transcription factors in mice and links its expression to IBD.

bioRxiv · Nov 3, 2021Cell Biology

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

B. Chen, E. T. McKinley, A. J. Simmons, M. A. Ramirez, X. Zhu, A. N. Southard-Smith, N. O. Markham, Q. Sheng, J. Drewes, Y. Xu, C. N. Heiser, Y. Zhou, F. Revetta, L. D. Berry, W. Zheng, , K. Lau

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

bioRxiv · Jan 11, 2021Cancer Biology

Murine intrarectal instillation of purified recombinant C. difficile toxins enables mechanistic studies of pathogenesis

N. O. Markham, S. C. Bloch, J. A. Shupe, E. N. Laubacher, M. K. Washington, R. J. Coffey, D. B. Lacy

This study uses purified recombinant C. difficile toxins in a mouse model to investigate their pathogenic mechanisms and tissue effects.

bioRxiv · Aug 30, 2020Microbiology

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.

M. A. Schumacher, J. J. Hsieh, C. Y. Liu, K. L. Appel, A. Waddell, D. Almohazey, K. Katada, J. K. Bernard, E. B. Bucar, S. Gadeock, K. M. Maselli, M. K. Washington, T. C. Grikscheit, D. Warburton, M. J. Rosen, M. R. Frey

This study shows that Sprouty2 restricts intestinal tuft and goblet cell numbers via GSK3β-mediated IL-33 expression, with implications for inflammatory bowel disease.

bioRxiv · Mar 9, 2020Physiology

Commensal-derived succinate enhances tuft cell specification and suppresses ileal inflammation

A. Banerjee, C. A. Herring, H. Kim, B. Chen, A. J. Simmons, A. N. Southard-Smith, J. R. White, M. A. Ramirez Solano, E. A. Scoville, Q. Liu, M. K. Washington, K. S. Lau

The paper shows that succinate from commensal bacteria promotes tuft cell development and reduces ileal inflammation in a mouse model of Crohn's disease.

bioRxiv · Sep 20, 2019Cell Biology

Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response

D. Maseda, J. P. Zackular, B. Trindade, L. Kirk, L. J. Crofford, P. D. Schloss, J. L. Roxas, V. K. Viswanathan, G. Vedantam, L. M. Rogers, M. K. Washington, E. P. Skaar, D. M. Aronoff

This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.

bioRxiv · Aug 14, 2018Microbiology