Author

D. M. Aronoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Gaddy· 3 shared C. R. McCutcheon· 2 shared L. M. Rogers· 2 shared S. D. Manning· 2 shared A. Eastman· 1 shared A. Hasty· 1 shared B. Jacobsson· 1 shared B. Trindade· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. Gaddy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Group B streptococcal membrane vesicles induce proinflammatory cytokine production and are sensed in an NLRP3 inflammasome-dependent mechanism in human macrophages

C. R. McCutcheon, J. Gaddy, D. M. Aronoff, S. D. Manning, M. G. Petroff

This study shows that GBS membrane vesicles induce proinflammatory cytokines in macrophages via NLRP3 inflammasome-dependent mechanisms, suggesting potential for immunotherapeutic targeting.

bioRxiv · Aug 10, 2022 · PreprintImmunology

Production and composition of group B streptococcal membrane vesicles varies across diverse lineages

C. R. McCutcheon, J. Gaddy, D. M. Aronoff, M. Petroff, S. D. Manning

This study quantifies membrane vesicle production and protein composition across diverse GBS strains, finding lineage-dependent variation in MVs that may influence clinical outcomes.

bioRxiv · Aug 24, 2021Microbiology

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages

L. Rogers, C. H. Serezani, A. Eastman, A. Hasty, L. Englund-Ogge, B. Jacobsson, K. Vickers, D. M. Aronoff

This study shows that palmitate induces NLRP3 inflammasome activation and apoptosis in human placental macrophages, while glucose and insulin do not contribute to these effects.

bioRxiv · Oct 10, 2019Immunology

Streptococcus agalactiae induces placental macrophages to release extracellular traps loaded with tissue remodeling enzymes via an oxidative-burst-dependent mechanism

R. S. Doster, J. Sutton, L. M. Rogers, D. M. Aronoff, J. Gaddy

This paper shows that placental macrophages release extracellular traps containing enzymes that kill GBS and may contribute to fetal membrane damage during infection.

bioRxiv · Oct 11, 2018Microbiology

Nonsteroidal anti-inflammatory drugs alter the microbiota and exacerbate Clostridium difficile colitis while dysregulating the inflammatory response

D. Maseda, J. P. Zackular, B. Trindade, L. Kirk, L. J. Crofford, P. D. Schloss, J. L. Roxas, V. K. Viswanathan, G. Vedantam, L. M. Rogers, M. K. Washington, E. P. Skaar, D. M. Aronoff

This study shows NSAIDs like indomethacin alter gut microbiota and worsen C. difficile colitis by disrupting PG metabolism, epithelial integrity, and immune responses in mice.

bioRxiv · Aug 14, 2018Microbiology