Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans
J. P. Rooney, K. A. Hershberger, E. A. Turner, L. J. Donoghue, L. L. Maurer, I. T. Ryde, J. J. Kim, R. Joglekar, J. D. Hibshman, L. L. Smith, D. P. Bhatt, O. R. Ilkayeva, M. D. Hirschey, J. N. Meyer
This study shows that early-life mitochondrial DNA damage in C. elegans causes lifelong energy production deficits through redox signaling mechanisms.
bioRxiv · Nov 25, 2020Cell Biology