Author

L. Lehtio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Organism:human· 1 Assay:proteomics· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. Galera-Prat· 2 shared M. M. Maksimainen· 2 shared S. Wazir· 2 shared A. Fehr· 1 shared A. Leung· 1 shared A. Roy· 1 shared A. Walker· 1 shared D. K. Johnson· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

A. Galera-Prat

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

L. M. Sherrill, E. E. Joya, A. Walker, A. Roy, Y. M. Alhammad, M. Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, D. K. Johnson, L. Lehtio, A. Fehr, D. V. Ferraris

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

bioRxiv · Feb 27, 2022 · PreprintBiochemistry

A molecular toolbox for ADP-ribosyl binding proteins

S. T. Sowa, A. Galera-Prat, S. Wazir, H. I. Alanen, M. M. Maksimainen, L. Lehtio

The paper develops a molecular toolbox for studying ADP-ribosyl binding proteins, including a fusion tag and high-affinity binders, and identifies suramin as an inhibitor of SARS-CoV-2 nsp3 macrodomain.

bioRxiv · May 31, 2021Biochemistry

Activation of ARTD2/PARP2 by DNA damage induces conformational changes relieving enzyme autoinhibition

E. Obaji, M. M. Maksimainen, A. Galera-Prat, L. Lehtio

The paper describes how DNA damage activates ARTD2/PARP2 through conformational changes that relieve autoinhibition and enable catalytic activity.

bioRxiv · Nov 24, 2020Biochemistry