Author

Y. M. Alhammad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Organism:virus· 1

Frequent Co-Authors

A. Roy· 3 shared D. K. Johnson· 3 shared A. Fehr· 2 shared A. Leung· 2 shared A. R. Fehr· 2 shared C. M. Kerr· 2 shared D. V. Ferraris· 2 shared J. J. O'Connor· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

A. Roy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

C. M. Kerr, J. J. Pfannenstiel, Y. M. Alhammad, J. J. O'Connor, R. Ghimire, R. Shrestha, R. Khattabi, P. Saenjamsai, S. Parthasarathy, P. R. McDonald, P. Gao, D. K. Johnson, S. More, A. Roy, R. Channappanavar, A. R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

A. Roy, Y. M. Alhammad, P. McDonald, D. K. Johnson, J. Zhuo, S. Wazir, D. V. Ferraris, L. Lehtiö, A. Leung, A. R. Fehr

This study identifies 5 compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding through high-throughput screening, with IC50 values under 100 µM.

bioRxiv · Mar 1, 2022Biochemistry

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

L. M. Sherrill, E. E. Joya, A. Walker, A. Roy, Y. M. Alhammad, M. Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, D. K. Johnson, L. Lehtio, A. Fehr, D. V. Ferraris

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

bioRxiv · Feb 27, 2022 · PreprintBiochemistry