Author

S. T. Sowa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Galera-Prat· 4 shared L. Lehtiö· 4 shared M. M. Maksimainen· 4 shared J. P. Heiskanen· 2 shared S. Murthy· 2 shared S. Wazir· 2 shared A. Fehr· 1 shared B. E. Lippok· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

A. Galera-Prat

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

S. Wazir, T. A. O. Parviainen, M. M. Maksimainen, M. T. H. Duong, J. J. Pfannenstiel, D. Cluff, S. T. Sowa, A. Galera-Prat, D. V. Ferraris, A. Fehr, J. P. Heiskanen, L. Lehtiö

This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes

S. Murthy, M. G. Nizi, M. M. Maksimainen, S. Massari, J. Alaviuhkola, B. E. Lippok, C. Vagaggini, S. T. Sowa, A. Galera-Prat, Y. Ashok, H. Venkannagari, R. Prunskaite-Hyyryläinen, E. Dreassi, B. Lüscher, P. Korn, , L. Lehtiö

The paper identifies a benzothiazole scaffold that inhibits multiple PARP enzymes with nanomolar potency, showing selectivity for mono-ARTs and poly-ARTs.

bioRxiv · Aug 29, 2022Biochemistry

The zinc-binding motif in tankyrases is required for the structural integrity and proper function of the catalytic domain

S. T. Sowa, L. Lehtiö

This study investigates the role of the zinc-binding motif in tankyrases, showing it is critical for structural integrity and activity, with differential effects on TNKS1 and TNKS2.

bioRxiv · Oct 4, 2021 · PreprintBiochemistry

Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs

M. M. Maksimainen, S. Murthy, S. T. Sowa, A. Galera-Prat, E. Rolina, J. P. Heiskanen, L. Lehtiö

The paper develops TIQ-A analogs that selectively inhibit mono-ADP-ribosyltransferases PARP10 and PARP15 over poly-ADP-ribosyltransferases, achieving 10-20-fold selectivity while maintaining micromolar potency.

bioRxiv · Aug 30, 2021Biochemistry

A molecular toolbox for ADP-ribosyl binding proteins

S. T. Sowa, A. Galera-Prat, S. Wazir, H. I. Alanen, M. M. Maksimainen, L. Lehtio

The paper develops a molecular toolbox for studying ADP-ribosyl binding proteins, including a fusion tag and high-affinity binders, and identifies suramin as an inhibitor of SARS-CoV-2 nsp3 macrodomain.

bioRxiv · May 31, 2021Biochemistry