Author

D. V. Ferraris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:virus· 1

Frequent Co-Authors

S. Wazir· 3 shared A. Fehr· 2 shared A. Leung· 2 shared A. Roy· 2 shared D. K. Johnson· 2 shared J. Zhuo· 2 shared L. Lehtiö· 2 shared Y. M. Alhammad· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

S. Wazir

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target

S. Wazir, T. A. O. Parviainen, M. M. Maksimainen, M. T. H. Duong, J. J. Pfannenstiel, D. Cluff, S. T. Sowa, A. Galera-Prat, D. V. Ferraris, A. Fehr, J. P. Heiskanen, L. Lehtiö

This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

A. Roy, Y. M. Alhammad, P. McDonald, D. K. Johnson, J. Zhuo, S. Wazir, D. V. Ferraris, L. Lehtiö, A. Leung, A. R. Fehr

This study identifies 5 compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding through high-throughput screening, with IC50 values under 100 µM.

bioRxiv · Mar 1, 2022Biochemistry

Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV-2 nsp3 Macrodomain

L. M. Sherrill, E. E. Joya, A. Walker, A. Roy, Y. M. Alhammad, M. Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, D. K. Johnson, L. Lehtio, A. Fehr, D. V. Ferraris

This study designs and synthesizes inhibitors targeting the SARS-CoV-2 nsp3 macrodomain, identifying compound 15c as a low-micromolar inhibitor with structural and thermal evidence of binding.

bioRxiv · Feb 27, 2022 · PreprintBiochemistry