Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient
C. A. Colque, P. E. Tomatis, A. G. Albarracin Orio, G. Dotta, D. M. Moreno, L. G. Hedemann, R. A. Hickman, L. M. Sommer, S. Feliziani, A. M. Moyano, R. A. Bonomo, H. K. Johansen, S. Molin, A. J. Vila, A. M. Smania
This study tracks the long-term evolution of antibiotic-resistant Pseudomonas aeruginosa in a cystic fibrosis patient, revealing diverse genetic changes that enhance resistance to multiple cephalosporins.
bioRxiv · May 14, 2021 · PreprintMicrobiology