Author

C. A. Colque

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

H. K. Johansen· 4 shared S. Molin· 4 shared A. M. Smania· 2 shared S. Feliziani· 2 shared A. Albarracin Orio· 1 shared A. Espaillat· 1 shared A. G. Albarracin Orio· 1 shared A. Hald· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

H. K. Johansen

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Author profile →

4 papers

Recent·Most cited

Cystic fibrosis systemic immune profile is associated with lung microbes and characterized by widespread alterations in the innate and adaptive immune compartments

E. Rossi, M. Lausen Nielsen, N. Friesgaard Obro, C. A. Colque, B. U. Nielsen, R. Moller, C. De Gier, A. Hald, M. Skov, T. Pressler, S. Molin, S. R. Ostrowski, H. V. Marquart, H. K. Johansen

This study identifies a specific immune profile in cystic fibrosis patients linked to lung microbiota and immune dysregulation, offering potential targets for treatment.

bioRxiv · Aug 23, 2023Immunology

Adaptive evolution of P. aeruginosa in human airways shows phenotypic convergence despite diverse patterns of genomic changes

A. Espaillat, C. A. Colque, D. Rago, R. La Rosa, S. Molin, H. K. Johansen

This study tracks Pseudomonas aeruginosa evolution in 9 cystic fibrosis patients over decades, finding phenotypic convergence despite genomic divergence and reduced virulence features.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Development of antibiotic resistance reveals diverse evolutionary pathways to face the complex and dynamic environment of a long-term treated patient

C. A. Colque, P. E. Tomatis, A. G. Albarracin Orio, G. Dotta, D. M. Moreno, L. G. Hedemann, R. A. Hickman, L. M. Sommer, S. Feliziani, A. M. Moyano, R. A. Bonomo, H. K. Johansen, S. Molin, A. J. Vila, A. M. Smania

This study tracks the long-term evolution of antibiotic-resistant Pseudomonas aeruginosa in a cystic fibrosis patient, revealing diverse genetic changes that enhance resistance to multiple cephalosporins.

bioRxiv · May 14, 2021 · PreprintMicrobiology

Hypermutator Pseudomonas aeruginosa exploits multiple genetic pathways to develop multidrug resistance during long term infections in the airways of cystic fibrosis patients

C. A. Colque, A. Albarracin Orio, S. Feliziani, R. L. Marvig, R. A. Tobares, H. K. Johansen, S. Molin, A. M. Smania

This study shows how hypermutator Pseudomonas aeruginosa strains develop multidrug resistance through parallel evolution of distinct genetic pathways during chronic cystic fibrosis infections.

bioRxiv · Oct 17, 2019Microbiology