Author

L. Maroc

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:C. elegans· 1 Assay:DNA methylation· 1 Organism:fungi (other)· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. S. Shapiro· 3 shared H. Shaker· 2 shared I. Gagnon-Arsenault· 2 shared J. Boisvert· 2 shared A. K. Dube· 1 shared A. Pageau· 1 shared C. Bedard· 1 shared C. Grant· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

R. S. Shapiro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A role for the putative error-prone polymerase REV1 in DNA damage and antifungal drug resistance in Candida albicans

M. R. Agyare-Tabbi, D. Uthayakumar, D. Francis, L. Maroc, C. Grant, P. McQueen, G. Westmacott, H. Shaker, I. Skulska, I. Gagnon-Arsenault, J. Boisvert, C. Landry, R. S. Shapiro

This study investigates the role of REV1, an error-prone polymerase, in DNA damage and antifungal drug resistance in Candida albicans, finding that its deletion increases mutation rates and resistance.

bioRxiv · Jun 24, 2024 · PreprintMicrobiology

Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost

C. Bedard, I. Gagnon-Arsenault, J. Boisvert, S. Plante, A. K. Dube, A. Pageau, J. Sharma, L. Maroc, R. S. Shapiro, C. R. Landry

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

bioRxiv · Dec 13, 2023 · PreprintMicrobiology

Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces glabrata via a novel CRISPR activation system

L. Maroc, H. Shaker, R. S. Shapiro

This paper develops and validates a CRISPR activation system in Nakaseomyces glabrata to study gene overexpression in pathogenesis and drug resistance.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology