Author

R. S. Shapiro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:C. elegans· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:gene regulatory network inference· 3 Approach:genetic perturbation / CRISPR· 3 Research Focus:differential expression· 2

Frequent Co-Authors

A. A. La Bella· 2 shared A. L. Flores-Mireles· 2 shared D. Uthayakumar· 2 shared G. H. Kim· 2 shared J. Sharma· 2 shared L. Maroc· 2 shared A. Chavez· 1 shared A. K. Dube· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

A. A. La Bella

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Author profile →

8 papers

Recent·Most cited

Most azole antifungal resistance mutations in the drug target provide cross-resistance and carry no intrinsic fitness cost

C. Bedard, I. Gagnon-Arsenault, J. Boisvert, S. Plante, A. K. Dube, A. Pageau, J. Sharma, L. Maroc, R. S. Shapiro, C. R. Landry

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

bioRxiv · Dec 13, 2023 · PreprintMicrobiology

Functional genetic characterization of stress tolerance and biofilm formation in Nakaseomyces glabrata via a novel CRISPR activation system

L. Maroc, H. Shaker, R. S. Shapiro

This paper develops and validates a CRISPR activation system in Nakaseomyces glabrata to study gene overexpression in pathogenesis and drug resistance.

bioRxiv · Dec 7, 2023 · PreprintMicrobiology

Antimicrobial susceptibility testing for diverse Malassezia species

B. Rathie, B. Theelen, M. Laurence, R. S. Shapiro

This study tests antimicrobial susceptibility of three Malassezia species to four drugs, finding isavuconazole and artemisinin effective and itraconazole most potent.

bioRxiv · Dec 9, 2022 · PreprintMicrobiology

Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans

N. C. Gervais, A. A. La Bella, L. F. Wensing, J. Sharma, V. Acquaviva, M. Best, R. O. Cadena Lopez, M. Fogal, D. Uthayakumar, A. Chavez, F. Santiago-Tirado, A. L. Flores-Mireles, R. S. Shapiro

This paper develops a CRISPR activation system for genetic overexpression in Candida albicans and demonstrates its ability to drive high-level gene expression and identify novel phenotypes.

bioRxiv · Aug 15, 2022Microbiology

The catheterized bladder environment promotes Efg1- and Als1-dependent Candida albicans infection

A. A. La Bella, M. J. Andersen, N. Gervais, J. J. Molina, A. Molesan, P. V. Stuckey, L. Wensing, C. J. Nobile, R. S. Shapiro, F. H. Santiago-Tirado, A. L. Flores-Mireles

This study identifies Efg1- and Als1-dependent mechanisms by which Candida albicans forms biofilms and causes infection in the catheterized bladder environment.

bioRxiv · Jun 1, 2021Microbiology

The SAGA and NuA4 component Tra1 regulates Candida albicans drug resistance and pathogenesis

I. Razzaq, M. D. Berg, Y. Jiang, J. Genereaux, D. Uthayakumar, G. H. Kim, C. J. Brandl, P. Lajoie, R. S. Shapiro

This study identifies Tra1 as a key regulator of drug resistance and pathogenesis in Candida albicans by analyzing gene expression and mutant phenotypes.

bioRxiv · Mar 17, 2021Microbiology

Systematic characterization and genetic interaction analysis of adhesins in Candida albicans virulence

S. Rosiana, L. Zhang, G. H. Kim, A. V. Revtovich, A. Sukumaran, J. Geddes-McAlister, N. V. Kirienko, R. S. Shapiro

The paper systematically characterizes adhesins in Candida albicans and identifies genetic interactions affecting virulence using a CRISPR-based mutant library and C. elegans model.

bioRxiv · Oct 22, 2020 · PreprintMicrobiology

Metabolism-Induced Oxidative Stress and DNA Damage Selectively Trigger Genome Instability in Polyploid Cells

G. J. Thomson, C. Hernon, N. Austriaco, R. S. Shapiro, P. Belenky, R. J. Bennett

The paper shows that metabolism-induced oxidative stress and DNA damage cause genome instability specifically in polyploid cells of C. albicans, not diploid cells.

bioRxiv · Nov 29, 2018Microbiology