Stress-induced clustering of the UPR sensor IRE1 is driven by disordered regions within its ER lumenal domain
P. Kettel, L. Marosits, E. Spinetti, M. Rechberger, P. Radler, I. Niedermoser, I. Fischer, G. A. Versteeg, M. Loose, R. Covino, G. E. Karagoz
This study shows that IRE1's ER lumenal domain forms dynamic condensates stabilized by membranes and unfolded polypeptides, which are essential for its clustering and signaling.
bioRxiv · Mar 30, 2023 · PreprintCell Biology