Author

G. A. Versteeg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Shulkina· 2 shared I. Schwartz· 2 shared J. Zuber· 2 shared K. Froussios· 2 shared R. Gogova· 2 shared T. Clausen· 2 shared V. Budroni· 2 shared A. Bestehorn· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

A. Shulkina

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stress-induced clustering of the UPR sensor IRE1 is driven by disordered regions within its ER lumenal domain

P. Kettel, L. Marosits, E. Spinetti, M. Rechberger, P. Radler, I. Niedermoser, I. Fischer, G. A. Versteeg, M. Loose, R. Covino, G. E. Karagoz

This study shows that IRE1's ER lumenal domain forms dynamic condensates stabilized by membranes and unfolded polypeptides, which are essential for its clustering and signaling.

bioRxiv · Mar 30, 2023 · PreprintCell Biology

SPOP targets the immune transcription factor IRF1 for proteasomal degradation

M. Vunjak, I. Schwartz, A. Cantoran-Garcia, M. Mastrovito, M. Hinterndorfer, M. de Almeida, V. Budroni, J. Wang, K. Froussios, J. Jude, T. Decker, J. Zuber, G. A. Versteeg

This study identifies SPOP as an E3 ligase that targets IRF1 for proteasomal degradation, highlighting its role in regulating IRF1 levels to balance immune response and tumor suppression.

bioRxiv · Oct 10, 2022Cell Biology

Structural basis of how the BIRC6/SMAC complex regulates apoptosis and autophagy

J. F. Ehrmann, D. B. Grabarczyk, M. Heinke, L. Deszcz, R. Kurzbauer, O. Hudecz, A. Shulkina, R. Gogova, A. Meinhart, G. A. Versteeg, T. Clausen

The paper determines the cryo-EM structure of BIRC6 and its complex with HTRA2 and SMAC, revealing how SMAC inhibits BIRC6 to regulate apoptosis and autophagy.

bioRxiv · Aug 30, 2022 · PreprintBiochemistry

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

S. Scinicariello, A. Soederholm, M. Schaefer, A. Shulkina, I. Schwartz, K. Hacker, R. Gogova, R. Kalis, K. Froussios, V. Budroni, A. Bestehorn, T. Clausen, P. Kovarik, J. Zuber, G. A. Versteeg

This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.

bioRxiv · Aug 29, 2022Cell Biology