M. Loose

Role of Dynamin-Related Proteins 2 and SH3P2 in Clathrin-Mediated Endocytosis in Plants

The paper investigates the role of DRP2s and SH3P2 in plant clathrin-mediated endocytosis, finding that DRP2s are recruited independently of BAR-SH3 proteins.

Impact of whole-genome duplications on structural variant evolution in the plant genus Cochlearia

This study examines how whole-genome duplications in Cochlearia plants increase structural variant diversity and its impact on adaptation to environmental changes.

Self-organisation of mortal filaments: the role of FtsZ treadmilling in bacterial division ring formation

The paper shows that FtsZ treadmilling drives nematic ordering in bacterial cells, enabling division ring formation through local dissolution of misaligned filaments.

Lack of detection of SARS-CoV-2 in British wildlife 2020-21 and first description of a stoat (Mustela erminea) Minacovirus

The paper tests British wildlife for SARS-CoV-2 and finds no infections but identifies a new minacovirus in stoats.

Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

The paper shows cortical Actin flows, driven by Myosin-2 depletion, mediate E-cadherin redistribution and cell contact formation.

Stress-induced clustering of the UPR sensor IRE1 is driven by disordered regions within its ER lumenal domain

This study shows that IRE1's ER lumenal domain forms dynamic condensates stabilized by membranes and unfolded polypeptides, which are essential for its clustering and signaling.

PRC domain-containing proteins modulate FtsZ-based archaeal cell division

This study identifies PRC domain proteins as essential components of the FtsZ-based cell division machinery in archaea, showing they form complexes with SepF and FtsZ and are required for proper cell division.

Sarbecoviruses of British Horseshoe Bats; Sequence Variation and Epidemiology

The paper tests for sarbecoviruses in British horseshoe bats, finding widespread infection in R. hipposideros but not R. ferrumequinum, and no evidence of human-to-bat transmission.

Chiral and nematic phases of flexible active filaments

The paper investigates how filament flexibility, density, and chirality influence the formation of chiral and nematic phases in FtsZ filaments during bacterial cell division.

Differential and defective expression of Koala Retrovirus indicate complexity of host and virus evolution

This study identifies defective KoRV variants in koalas previously thought to be KoRV-free, suggesting historical exposure and potential protective effects against infectious KoRV.

In vitro reconstitution of divisome activation

This study uses biochemical and imaging methods to investigate how FtsA activates the bacterial divisome by switching between polymer and monomer states, revealing its role in FtsZ dynamics and FtsN recruitment.

The TPLATE complex mediates membrane bending during plant clathrin-mediated endocytosis

The paper identifies the TPLATE complex as a mediator of membrane bending in plant clathrin-mediated endocytosis, which occurs independently of actin and against high turgor pressure.

Real time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin binding proteins

The paper develops a FRET-based assay to monitor peptidoglycan synthesis in real time using membrane-reconstituted class A penicillin binding proteins from different bacteria.

Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion

The paper measures microtubule depolymerization rates in Xenopus egg extract asters and finds higher rates in the interior compared to the periphery, suggesting regulation by MAP depletion.

Computational analysis of filament polymerization dynamics in cytoskeletal networks

The paper introduces an automated image analysis workflow to study polymerization dynamics of cytoskeletal filaments using time-lapse microscopy data.

ZapA stabilizes FtsZ filament bundles without slowing down treadmilling dynamics

This study shows ZapA stabilizes FtsZ filament bundles in vitro without affecting treadmilling speed, explaining how Z-ring architecture is maintained.

FtsZ assembles the bacterial cell division machinery by a diffusion-and-capture mechanism

The paper shows FtsZ treadmilling recruits divisome proteins via diffusion-and-capture, explaining how the Z-ring dynamically assembles the bacterial cell division machinery.

Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

This paper develops a low-cost WGS method for TB diagnosis and surveillance using direct respiratory samples, achieving rapid results with high concordance with reference labs.