Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase
R. Beale, A. P. Bertolin, A. Borg, B. Canal, J. F. Diffley, L. S. Drury, R. Harvey, M. Howell, S. Hussain, S. Kjaer, J. McCauley, L. McCoy, J. Milligan, V. Posse, C. Roustan, , J. Zeng
This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.
bioRxiv · Apr 7, 2021Biochemistry