Author

J. Mccauley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. Harvey· 6 shared S. Hussain· 6 shared N. Faulkner· 4 shared R. Beale· 4 shared S. Gamblin· 4 shared S. Kjaer· 4 shared C. Swanton· 3 shared G. Kassiotis· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

R. Harvey

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Broad human and animal coronavirus neutralisation by SARS-CoV-2 S2-targeted vaccination

K. Ng, N. Faulkner, K. Finsterbusch, M. Wu, R. Harvey, S. Hussain, M. Greco, Y. Liu, S. Kjaer, C. Swanton, S. Gandhi, R. Beale, S. Gamblin, P. Cherepanov, J. Mccauley, , G. Kassiotis

This study shows that SARS-CoV-2 S2-targeted vaccination induces broad neutralizing antibodies against multiple coronaviruses and provides better protection than homologous boosting.

bioRxiv · Nov 30, 2021 · PreprintImmunology

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

R. Beale, A. P. Bertolin, A. Borg, B. Canal, J. F. Diffley, L. S. Drury, R. Harvey, M. Howell, S. Hussain, S. Kjaer, J. McCauley, L. McCoy, J. Milligan, V. Posse, C. Roustan, , J. Zeng

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

N. Faulkner, K. Ng, M. Wu, R. Harvey, S. Hussain, M. Greco, W. Bolland, S. Warchal, M. Margaritis, S. Paraskevopoulou, J. Heaney, H. Rickman, C. Houlihan, M. Spyer, D. Frampton, , G. Kassiotis

This study compares antibody cross-reactivity between SARS-CoV-2 B.1.1.7 and parental strains, finding reduced recognition and neutralization of older variants after B.1.1.7 infection.

bioRxiv · Mar 1, 2021Immunology

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

C. Deakin, G. Cornish, K. Ng, N. Faulkner, W. Bolland, V. Panova, J. Hope, A. Rosa, R. Harvey, S. Hussain, C. Earl, B. Jebson, M. Wilkinson, L. Marshall, K. O'Brien, , G. Kassiotis

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

bioRxiv · Feb 15, 2021 · PreprintImmunology

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

K.-Y. A. Huang, T. Tan, T.-H. Chen, C.-G. Huang, R. Harvey, S. Hussain, C.-P. Chen, A. Harding, J. Gilbert-Jaramillo, X. Liu, M. Knight, L. Schimanski, S.-R. Shih, Y.-C. Lin, C.-Y. Cheng, , A. Townsend

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

bioRxiv · Aug 28, 2020 · PreprintMicrobiology

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

K. W. Ng, N. Faulkner, G. Cornish, A. Rosa, R. Harvey, S. Hussain, R. Ulferts, C. Earl, A. Wrobel, D. Benton, C. Roustan, W. Bolland, R. Thompson, A. Agua-Doce, P. Hobson, , Mc

The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.

bioRxiv · May 14, 2020Immunology