Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation
V. Martinez-Heredia, D. Blackwell, S. Sebastian, T. Pearson, G. F. Mok, L. Mincarelli, C. Utting, L. Folkes, E. Poschl, I. C. Macaulay, U. C. Mayer, A. E. Munsterberg
This study shows that Talpid3 is essential for muscle stem cell self-renewal and regeneration, and pharmacological Wnt activation can restore regeneration in its absence.
bioRxiv · Oct 14, 2022Cell Biology