I. C. Macaulay

Low protein diet protects liver function upon Salmonella infection by metabolic reprogramming of macrophages

This study shows that a low protein diet reduces liver damage from Salmonella infection by altering macrophage metabolism and autophagy.

Automated Purification of DNA Origami with SPRI Beads

This paper introduces SPRI beads as an automated, scalable method for purifying DNA origami, achieving comparable yield and structural integrity while enabling high-throughput processing.

Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation

This study shows that Talpid3 is essential for muscle stem cell self-renewal and regeneration, and pharmacological Wnt activation can restore regeneration in its absence.

Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding

This study uses RNA barcoding and single-cell RNA-seq to analyze clonal dynamics of hematopoietic stem cells, showing that platelet depletion shifts HSC output to platelets and new myeloid clones.

High expression of VRT2 increases the number of rudimentary basal spikelets in wheat

The paper identifies a transcriptional gradient in wheat spikes associated with rudimentary basal spikelet development, leading to the lanceolate spike shape.

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.