M. Eldridge

In Breast Cancer ZMIZ1 Co-Regulates E2F2 as Part of the Estrogen Receptor-Mediated Cell-Cycle Response

This study identifies ZMIZ1 as a co-regulator of E2F2 in the estrogen receptor-mediated cell-cycle response in breast cancer, showing its role in tumor proliferation and patient prognosis.

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

The paper identifies frequent allelic expression imbalance of PIK3CA mutations in breast cancer and links it to poor prognosis.

Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer

This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.

Streptococcus pneumoniae infection promotes histone H3 dephosphorylation by modulating host PP1 phosphatase

This study shows Streptococcus pneumoniae infection causes histone H3 dephosphorylation at serine 10 via host PP1 phosphatase activation, enhancing bacterial survival.

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.

The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic

This study identifies 77 driver genes and 21 non-coding driver elements in 551 Esophageal Adenocarcinomas, linking them to clinical outcomes and therapeutic targets.

Copy-number signatures and mutational processes in ovarian carcinoma

This study identifies copy-number signatures in ovarian cancer and links them to mutational processes, showing that most cases involve multiple processes, suggesting therapeutic challenges.