K. Saeb-Parsy

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age

The paper profiles immune cell RNA and protein expression across tissues and age to identify tissue-specific and age-related immune signatures.

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

Hiding in Plain Sight: Thymic CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.

Epithelioids: Self-sustaining 3D epithelial cultures to study long-term processes

This paper introduces epithelioids, a 3D culture system for mouse and human epithelia that maintains structure and function over long periods, enabling study of long-term biological processes.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood

The paper identifies two distinct subsets of human marginal zone B cells through global analysis of lymphoid tissues and blood, revealing differences in their biology and distribution.

Densified Collagen Tubular Grafts for Human Tissue Replacement and Disease Modelling Applications

This paper develops a cell-free, densified collagen tubular graft that is mechanically strong, customizable, and supports cell incorporation for tissue replacement and disease modeling.

Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism

This study shows that loss of RNF43/ZNRF3 leads to liver cancer by disrupting lipid metabolism and impairing liver regeneration in mice, with similar effects observed in human patients.

A cell atlas of human thymic development defines T cell repertoire formation

This study creates a cell atlas of the human thymus using scRNA-seq, revealing new cell populations and insights into T-cell development and TCR recombination.

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

This study compares HSPC landscapes in bone marrow, spleen, and peripheral blood using single-cell RNA-seq, revealing distinct molecular and functional differences in haematopoiesis across these sites.

Distinct microbial and immune niches of the human colon

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

The mutational landscape of normal human endometrial epithelium

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.

The landscape of somatic mutation in normal colorectal epithelial cells

This study whole genome sequences normal colorectal crypts to reveal mutational processes and driver mutations in morphologically normal tissue, showing neoplastic changes are pervasive.