PI3Kδ inhibition supports memory T cells with enhanced antitumor fitness
J. S. Bowers, K. Majchrzak, M. H. Nelson, B. A. Aksoy, M. M. Wyatt, A. S. Smith, S. R. Bailey, L. Neal, J. Hammerbacher, C. M. Paulos
This paper shows that inhibiting PI3Kδ with CAL-101 enhances CD8+ T cell memory and antitumor efficacy in both murine and human models.
bioRxiv · Jul 20, 2017Cancer Biology