Author

C. M. Paulos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:proteomics· 8 Research Focus:cancer & tumor microenvironment· 7 Organism:mouse· 7 Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. M. Wyatt· 7 shared A. S. Smith· 5 shared G. O. Rangel Rivera· 5 shared H. M. Knochelmann· 5 shared G. B. Lesinski· 4 shared C. J. Dwyer· 3 shared D. M. Neskey· 3 shared J. E. Thaxton· 3 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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7 shared papersImmunology

M. M. Wyatt

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Distinct host preconditioning regimens differentially impact the antitumor potency of adoptively transferred Th17 cells.

M. C. Wittling, H. M. Knochelmann, M. M. Wyatt, G. O. Rangel Rivera, A. C. Cole, G. B. Lesinski, C. M. Paulos

This study compares the effects of two host preconditioning methods on the antitumor activity of adoptively transferred Th17 cells, finding that total body irradiation enhances their efficacy more than chemotherapy.

bioRxiv · Dec 18, 2023Cancer Biology

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

G. O. Rangel Rivera, C. J. Dwyer, H. Knochelmann, A. S. Smith, B. A. Aksoy, A. C. Cole, M. M. Wyatt, J. E. Thaxton, G. B. Lesinski, C. M. Paulos

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

bioRxiv · Mar 8, 2023 · PreprintImmunology

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

M. M. Wyatt, L. W. Huff, M. H. Nelson, L. R. Neal, A. R. Medvec, G. O. Rangel Rivera, A. S. Smith, A. M. Rivera Reyes, H. M. Knochelmann, J. L. Riley, G. B. Lesinski, C. M. Paulos

This study shows that reducing TCR and co-stimulation signal strength in Th17 cell manufacturing enhances their metabolic fitness and antitumor efficacy in mesothelioma models.

bioRxiv · Oct 28, 2022Immunology

Stress-Mediated Attenuation of Translation Undermines T Cell Tumor Control

B. P. Riesenberg, E. G. Hunt, M. D. Tennant, K. E. Hurst, A. M. Andrews, L. R. Leddy, D. M. Neskey, E. G. Hill, G. O. R. Rivera, C. M. Paulos, P. Gao, J. E. Thaxton

This study shows that solid tumor microenvironment stress reduces T cell protein translation via the UPR and p-eIF2, and that proteasome stimulation can reverse this effect to enhance antitumor immunity.

bioRxiv · Jan 31, 2022 · PreprintImmunology

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

A. S. Smith, H. M. Knochelmann, M. M. Wyatt, G. O. Rangel Rivera, A. M. Rivera-Reyes, C. J. Dwyer, D. M. Neskey, M. P. Rubinstein, B. Liu, J. E. Thaxton, E. Bartee, C. M. Paulos

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.

bioRxiv · Mar 16, 2021Immunology

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies

H. M. Knochelmann, A. M. Rivera-Reyes, M. M. Wyatt, A. S. Smith, R. Chamness, C. J. Dwyer, M. Bobian, G. O. Rangel Rivera, J. D. Horton, M. Lilly, M. P. Rubinstein, D. M. Neskey, C. M. Paulos

The paper expands murine tumor-infiltrating lymphocytes ex vivo in IL-2 and compares their phenotypes to human TILs from oral cavity cancer patients.

bioRxiv · Feb 4, 2021Immunology

Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T cell-dependent manner.

M. B. Ware, C. McQuinn, M. Y. Zaidi, H. Knochelmann, T. A. Mace, Z. Chen, C. Zhang, M. R. Farren, A. N. Ruggieri, J. Bowers, R. Shakya, A. B. Farris, G. Young, W. E. Carson, B. El-Rayes, , G. B. Lesinski

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

bioRxiv · Feb 7, 2020 · PreprintCancer Biology

Identification of human CD4+ T cell populations with distinct antitumor activity

M. H. Nelson, H. M. Knochelmann, S. R. Bailey, L. W. Huff, J. S. Bowers, K. Majchrzak, M. M. Wyatt, M. P. Rubinstein, S. Mehrotra, M. I. Nishimura, K. Armeson, P. G. Giresi, M. J. Zilliox, H. E. Broxmeyer, C. M. Paulos

The paper identifies human CD4+ T cell populations with distinct antitumor activity, showing CD26high T cells are epigenetically and transcriptionally different from Th17 cells and are more effective in tumor therapy.

bioRxiv · Dec 31, 2019Immunology

PI3Kδ inhibition supports memory T cells with enhanced antitumor fitness

J. S. Bowers, K. Majchrzak, M. H. Nelson, B. A. Aksoy, M. M. Wyatt, A. S. Smith, S. R. Bailey, L. Neal, J. Hammerbacher, C. M. Paulos

This paper shows that inhibiting PI3Kδ with CAL-101 enhances CD8+ T cell memory and antitumor efficacy in both murine and human models.

bioRxiv · Jul 20, 2017Cancer Biology