A. S. Smith

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cell therapy

This study shows that reducing TCR and co-stimulation signal strength in Th17 cell manufacturing enhances their metabolic fitness and antitumor efficacy in mesothelioma models.

B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity

This study shows that CpG-mediated expansion with B cells enhances CD8+ T cell tumor immunity by inducing a unique proteomic signature and specific surface markers.

Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies

The paper expands murine tumor-infiltrating lymphocytes ex vivo in IL-2 and compares their phenotypes to human TILs from oral cavity cancer patients.

Non-uniform distribution of myosin-mediated forces governs red blood cell membrane curvature through tension modulation

This study shows that non-uniform myosin-mediated forces modulate RBC membrane curvature by altering tension distribution, with higher forces in the dimple region.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability

This paper shows that myosin IIA interacts with the spectrin-actin membrane skeleton in red blood cells to control membrane curvature and deformability by exerting contractile forces.

PI3Kδ inhibition supports memory T cells with enhanced antitumor fitness

This paper shows that inhibiting PI3Kδ with CAL-101 enhances CD8+ T cell memory and antitumor efficacy in both murine and human models.