Author

L. Niedernhofer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

D. Monroe· 3 shared D. Saul· 3 shared M. L. Doolittle· 3 shared N. LeBrasseur· 3 shared D. Jurk· 2 shared J. Passos· 2 shared M.D, S. Khosla· 2 shared P. D. Robbins· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

D. Monroe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Distinct secretomes in p16- and p21- positive senescent cells across tissues

D. Saul, D. Jurk, M. L. Doolittle, R. L. Kosinsky, D. Monroe, N. LeBrasseur, P. D. Robbins, L. Niedernhofer, M.D, S. Khosla, J. Passos

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

bioRxiv · Dec 5, 2023 · PreprintCell Biology

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P. Samakkarnthai, D. Saul, L. Zhang, Z. Aversa, M. L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, , S. Khosla

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Aging · May 7, 2023Peer-reviewedPhysiology

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

D. Saul, R. L. Kosinsky, E. J. Atkinson, M. L. Doolittle, X. Zhang, N. LeBrasseur, R. Pignolo, P. Robbins, L. Niedernhofer, Y. Ikeno, D. Jurk, J. Passos, L. Hickson, A. Xue, D. Monroe, , M.D, S. Khosla

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

bioRxiv · Dec 10, 2021Cell Biology