Author

T. Tchkonia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

J. L. Kirkland· 4 shared N. LeBrasseur· 3 shared D. Jurk· 2 shared D. Monroe· 2 shared D. Saul· 2 shared L. Niedernhofer· 2 shared M. L. Doolittle· 2 shared R. Pignolo· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

J. L. Kirkland

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P. Samakkarnthai, D. Saul, L. Zhang, Z. Aversa, M. L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, , S. Khosla

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Aging · May 7, 2023Peer-reviewedPhysiology

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

S. Chaib, J. A. Lopez-Dominguez, M. Lalinde, N. Prats, I. Marin, K. Meyer, M. I. Munoz, M. Aguilera, L. Mateo, C. S.-O. Attolini, S. Llanos, M. Escorihuela, S. Perez-Ramos, F. Al-Shahrour, T. P. Cash, , M. Serrano

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

bioRxiv · Nov 4, 2022 · PreprintCancer Biology

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

D. Saul, R. L. Kosinsky, E. J. Atkinson, M. L. Doolittle, X. Zhang, N. LeBrasseur, R. Pignolo, P. Robbins, L. Niedernhofer, Y. Ikeno, D. Jurk, J. Passos, L. Hickson, A. Xue, D. Monroe, , M.D, S. Khosla

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

bioRxiv · Dec 10, 2021Cell Biology

Aged-senescent cells contribute to impaired heart regeneration

F. C. Lewis-McDougall, P. J. Ruchaya, E. Domenjo-Vila, T. S. Teoh, L. Prata, B. J. Cottle, J. E. Clark, P. P. Punjabi, W. Awad, D. Torella, T. Tchkonia, J. L. Kirkland, G. M. Ellison-Hughes

This study shows that aged-senescent cardiac progenitor cells impair heart regeneration and that eliminating them improves cardiac function in aged mice.

bioRxiv · Oct 1, 2018Physiology

Length-independent telomere damage drives cardiomyocyte senescence

R. Anderson, A. Lagnado, D. Maggiorani, A. Walaszczyk, E. Dookun, J. Chapman, J. Birch, H. Salmonowicz, M. Ogrodnik, D. Jurk, C. Proctor, C. Correia-Melo, S. Victorelli, E. Fielder, R. Berlinguer-Palmini, , J. F. Passos

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.

bioRxiv · Aug 17, 2018Cell Biology