Author

J. Kirkland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. E. Warrington· 1 shared A. Howard· 1 shared B. Zhang· 1 shared D. Brown· 1 shared D. Monroe· 1 shared D. Saul· 1 shared E. Atkinson· 1 shared E. F. Sananikone· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. E. Warrington

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P. Samakkarnthai, D. Saul, L. Zhang, Z. Aversa, M. L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, , S. Khosla

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Aging · May 7, 2023Peer-reviewedPhysiology

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

B. Zhang, Q. Long, S. Wu, S. Song, Q. Xu, L. Han, M. Qian, X. Ren, J. Jiang, Q. Fu, J. Guo, X. Zhang, X. Chang, E. Lam, J. Campisi, , Y. Sun

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Nature Aging · May 13, 2021Peer-reviewedCell Biology

Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

M. Rahman, I. E. Olson, M. Mansour, L. P. Carlstrom, R. Sutiwisesak, R. Saber, K. Rajani, A. E. Warrington, A. Howard, M. Schroeder, S. Chen, P. A. Decker, Y. Zhu, I. F. Parney, S. Burma, , E. F. Sananikone

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

bioRxiv · Jun 3, 2020Cancer Biology