D. Jurk

Distinct secretomes in p16- and p21- positive senescent cells across tissues

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

The paper shows that short anti-senescence interventions reduce radiation-induced frailty and premature ageing in mice, improving muscle, liver function, and memory.

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

Temporal inhibition of autophagy reveals segmental reversal of aging with increased cancer risk

This study shows that inhibiting autophagy in mammals accelerates aging and increases cancer risk, while restoring autophagy extends lifespan but does not fully prevent cancer.

Length-independent telomere damage drives cardiomyocyte senescence

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.