Author

L. P. Gondek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Apffel· 1 shared A. R. Moliterno· 1 shared B. Paun· 1 shared B. Perkins· 1 shared C. A. Meyer· 1 shared C. Bonifant· 1 shared C. Esteb· 1 shared C. J. Gibson· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Apffel

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2 papers

Recent·Most cited

The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia

T. KARANTANOS, P. Teodorescu, B. Perkins, I. Christodolou, C. Esteb, R. Varadhan, E. Helmenstine, T. Rajkhowa, B. Paun, C. Bonifant, W. B. Dalton, L. P. Gondek, A. R. Moliterno, M. J. Levis, G. Ghiaur, R. J. Jones

This study identifies CCRL2 as a mediator of MDS and secondary acute myeloid leukemia growth through JAK2/STAT signaling, with potential therapeutic implications.

bioRxiv · Jul 29, 2021Cancer Biology

BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes

E. J. Schaefer, W. C. Wang, C. A. Meyer, P. Cejas, M. D. Gearhart, E. R. Adelman, I. Fares, A. Apffel, K. Lim, Y. Xie, C. J. Gibson, M. Schenone, H. M. Murdock, E. S. Wang, L. P. Gondek, , R. C. Lindsley

This study shows BCOR and BCORL1 mutations disrupt PRC1.1 function in leukemia by separating its enzymatic core from chromatin targets, leading to treatment resistance.

bioRxiv · Mar 8, 2021 · PreprintCancer Biology