Author

M. D. Gearhart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

V. J. Bardwell· 3 shared A. Apffel· 1 shared A. B. Nelson· 1 shared A. Korshunov· 1 shared A. L. Mercier· 1 shared B. A. Orr· 1 shared B. Statz· 1 shared C. A. Meyer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

V. J. Bardwell

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Author profile →

4 papers

Recent·Most cited

Human Trophoblast Stem Cells Restrict Human Cytomegalovirus Replication

T. B. Rollman, Z. W. Berkebile, H. Okae, V. J. Bardwell, M. D. Gearhart, C. J. Bierle

This study shows that human trophoblast stem cells restrict HCMV replication but alter gene expression related to differentiation and cell fate, potentially impairing placental function.

bioRxiv · Dec 13, 2023Microbiology

Metformin impairs trophoblast metabolism and differentiation in dose dependent manner

S. K. Nashif, R. M. Mahr, S. Jena, S. Jo, A. B. Nelson, D. Sadowski, P. A. Crawford, P. Puchalska, E. U. Alejandro, M. D. Gearhart, S. A. Wernimont

This study shows that high-dose metformin impairs trophoblast metabolism and differentiation, while therapeutic doses do not.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes

E. J. Schaefer, W. C. Wang, C. A. Meyer, P. Cejas, M. D. Gearhart, E. R. Adelman, I. Fares, A. Apffel, K. Lim, Y. Xie, C. J. Gibson, M. Schenone, H. M. Murdock, E. S. Wang, L. P. Gondek, , R. C. Lindsley

This study shows BCOR and BCORL1 mutations disrupt PRC1.1 function in leukemia by separating its enzymatic core from chromatin targets, leading to treatment resistance.

bioRxiv · Mar 8, 2021 · PreprintCancer Biology

Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

L. M. Kutscher, K. Okonechnikov, N. V. Batora, J. Clark, P. B. G. Silva, M. Vouri, S. van Rijn, L. Sieber, B. Statz, M. D. Gearhart, N. Mack, B. A. Orr, A. Korshunov, A. L. Mercier, O. Ayrault, , D. Kawauchi

This study shows that loss of BCOR in SHH-medulloblastoma accelerates tumor formation by disrupting the BCOR-PRC1.1 complex and increasing Igf2 expression.

bioRxiv · Feb 6, 2020Cancer Biology