ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells
P. Verma, Y. Zhou, Z. Cao, P. Deraska, M. Deb, E. Arai, W. Li, Y. Shao, Y. Li, L. Puentes, s. patankar, R. H. Mach, R. B. Faryabi, J. Shi, R. A. Greenberg
This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.
bioRxiv · Dec 16, 2020Cancer Biology