Author

R. H. Mach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

E. J. Petersson· 2 shared A. E. Dulcey· 1 shared A. N. Nilson· 1 shared A. Riad· 1 shared B. C. Capell· 1 shared B. Garcia· 1 shared C. Zeng· 1 shared D. R. Sibley· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

E. J. Petersson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification and Characterization of ML321: a Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

R. B. Free, A. N. Nilson, N. M. Boldizsar, T. Doyle, R. M. Rodriguiz, V. M. Pogorelov, M. Machino, K. H. Lee, J. W. Bertz, J. Xu, H. D. Lim, A. E. Dulcey, R. H. Mach, J. H. Woods, J. R. Lane, , D. R. Sibley

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

bioRxiv · Nov 14, 2022Pharmacology & Toxicology

Harnessing the Intrinsic Photochemistry of Isoxazoles for the Development of Chemoproteomic Crosslinking Methods

M. G. Lougee, V. V. Pagar, H. J. Kim, S. X. Pancoe, R. H. Mach, B. Garcia, E. J. Petersson

This paper introduces a new photo-crosslinking method using isoxazole's intrinsic photochemistry, validated across multiple proteins in vitro and ex vivo.

bioRxiv · Dec 23, 2021Biochemistry

Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake

A. Riad, Y. Aubert, C. Zeng, T. J. A. Graham, E. J. Petersson, B. C. Capell, R. H. Mach

This study uses RNA-Seq to identify differentially expressed genes in sigma-2R/TMEM97 knockout cells, revealing its role in complement activation and SARS-CoV-2 viral uptake.

bioRxiv · Mar 14, 2021 · PreprintCell Biology

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells

P. Verma, Y. Zhou, Z. Cao, P. Deraska, M. Deb, E. Arai, W. Li, Y. Shao, Y. Li, L. Puentes, s. patankar, R. H. Mach, R. B. Faryabi, J. Shi, R. A. Greenberg

This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.

bioRxiv · Dec 16, 2020Cancer Biology