Y. Shao

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound-Inflicted Cell Ablation

This study develops a platform to investigate ultrasound-induced cell ablation and wound healing, revealing subcellular cavitation bubbles as a mechanism of mechanolysis and a phantom layer guiding collective healing.

Siderophore synthetase-receptor gene coevolution reveals habitat- and pathogen-specific bacterial iron interaction networks

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

Scalable gradients enable Hamiltonian Monte Carlo sampling for phylodynamic inference under episodic birth-death-sampling models

This paper introduces a gradient-based Hamiltonian Monte Carlo sampler for efficient inference in episodic birth-death-sampling models, showing significant computational improvements over Metropolis-Hastings methods.

Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

This study identifies cardiac glycosides that restore autophagy and gene expression in an iPSC model of WDR45 deficiency, suggesting potential therapeutic applications for BPAN.

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimers Disease Models

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

A Subtle Balance between Host Selection and Microbial Size Effect Mediates Plant Microbiome Assembly in Mulberry

The paper investigates plant microbiome assembly in mulberry, finding that host selection and microbial size influence biogeographic patterns and community dynamics.

Cuproptosis is correlated with clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: a multi-omic analysis

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity

This study uses CRISPR/Cas9 screens to identify RARA and SPNS1 as genetic modifiers of doxorubicin cardiotoxicity, revealing their roles in cell death and drug accumulation.

Strong pathogen competition in neonatal gut colonisation

This study quantifies strain-level colonisation dynamics of gut pathogens in neonates, finding strong competition and some synergies, and reveals pathogenic potential differences among ExPEC clones.

The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.

Drivers of nematode diversity in forest soils across climatic zones

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

Invasiveness of Cancer Populations in a Two-dimensional Percolation cluster: a Stochastic Mathematical Approach

The paper develops a stochastic mathematical framework to quantify cancer invasiveness using finite time scaling and simulations of cell population dynamics.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

This study shows NSD2 E1099K mutation disrupts 3D chromatin organization in B-ALL, leading to drug resistance and clonal evolution through compartmentalization changes.

Deactivation of SARS-CoV-2 surrogate porcine epidemic diarrhea virus with electron beam irradiation under the cold chain transportation condition

This study evaluates the effectiveness of high-energy electron beam irradiation in deactivating SARS-CoV-2 surrogate virus PEDV under cold chain conditions.

Directional Cell Migration Guided by a Strain Gradient

This study shows that strain gradients can drive directional cell migration in rat embryonic fibroblasts, distinct from durotaxis or haptotaxis.

Amelioration of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

Multiple Mechanisms of HIV-1 resistance to PGT135 in Chinese Subtype B' Slow Progressor

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells

This study identifies ALC1 as a key determinant of PARPi toxicity in HR-deficient cells by linking PARP-dependent chromatin remodeling to PARPi response.

Apical-root apoplastic acidification affects cell-wall extensibility in wheat under salinity stress

This study investigates how apoplastic pH and expansin expression affect cell-wall extensibility in wheat roots under salinity stress, revealing differences between salt-tolerant and sensitive cultivars.

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

Intestinal-derived FGF15 preserves muscle and bone mass following sleeve gastrectomy

This study shows that intestinal FGF15 protects against muscle and bone loss after sleeve gastrectomy in mice.

VST Family Proteins are Regulators of Root System Architecture in Rice and Arabidopsis

This study identifies OsVST1 in rice and its homologs in Arabidopsis as regulators of root system architecture, showing conserved function and potential for agricultural optimization.

Functional Interrogation of HOXA9 Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors

This study shows cabozantinib enhances neutrophil-mediated delivery of nanoparticles to prostate tumors in mice, leading to higher NP accumulation in the tumor microenvironment.