Author

Sophie Rouvray

University of BirminghamORCID 0009-0008-8828-1447Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

David BendingiD· 3 shared Lozan SheriffiD· 3 shared Alastair CoplandiD· 2 shared David A.J. LeckyiD· 2 shared Rebecca A. DrummondiD· 2 shared Andrew D. SouthamiD· 1 shared Callum ClarkiD· 1 shared Chloe Wellings· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

David BendingORCID

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3 papers

Recent·Most cited

ImmunologymBioPeer-reviewedApr 29, 2026

Vancomycin impairs macrophage fungal killing by disrupting mitochondrial morphology and function

Ebrima Bojang, Lozan Sheriff, Emma Morris…·Rebecca A. Drummond

This study shows vancomycin impairs macrophage fungal killing by disrupting mitochondrial function and morphology, independent of microbiome effects.

1 citation

humanproteomics

𝕏 PostBluesky

ImmunologyiSciencePeer-reviewedMar 31, 2025

Interferonγ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

David A.J. Lecky, Lozan Sheriff, Sophie T. Rouvray…·David Bending

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

2 citations

mousebulk RNA-seq

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ImmunologyImmunotherapy AdvancesPeer-reviewedDec 30, 2024

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

Lozan Sheriff, Alastair Copland, David A.J. Lecky…·David Bending

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

5 citations

mousebulk RNA-seq

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