Author

L. S. Prahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:development & morphogenesis· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Organism:human· 2 Assay:imaging· 2 Assay:organoid / primary culture· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. J. Hughes· 5 shared J. Liu· 4 shared J. M. Viola· 4 shared A. Huang· 3 shared C. M. Porter· 3 shared D. J. Odde· 2 shared A. C. Chang· 1 shared A. Gupta· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersBioengineering

A. J. Hughes

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Author profile →

7 papers

Recent·Most cited

Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation

J. Liu, L. S. Prahl, A. Huang, A. J. Hughes

MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.

bioRxiv · Feb 7, 2024 · PreprintBioengineering

Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches

J. M. Viola, J. Liu, A. Huang, S. H. Grindel, L. S. Prahl, A. J. Hughes

This study shows that Rho/ROCK inhibition enhances mixing between nephron progenitor and stromal cells, increasing nephrogenesis in kidney organoids.

bioRxiv · Nov 8, 2023 · PreprintBioengineering

Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology

L. S. Prahl, C. M. Porter, J. M. Viola, J. Liu, A. J. Hughes

This paper develops a method to independently control cell patterning and adhesion on hydrogels to study tissue interfaces and mechanobiology.

bioRxiv · Nov 16, 2022Bioengineering

Tubule jamming in the developing mouse kidney creates cyclical mechanical stresses in nephron-forming niches

J. M. Viola, J. Liu, L. S. Prahl, A. Huang, T. J. Chan, G. Hayward-Lara, C. M. Porter, C. Shi, J. Zhang, A. J. Hughes

The paper investigates how crowding in developing mouse kidney tubules creates mechanical stresses in nephron-forming niches, revealing how spatial constraints influence branching and nephron formation.

bioRxiv · Jun 3, 2022 · PreprintBioengineering

Kinomorphs: Shape-shifting tissues for developmental engineering

J. M. Viola, C. M. Porter, A. Gupta, M. Alibekova, L. S. Prahl, A. J. Hughes

This paper introduces kinomorphs, dynamic scaffolds that guide large-scale tissue assembly through programmed shape changes, enabling the creation of structurally mature epithelial tubules.

bioRxiv · Sep 14, 2019 · PreprintBioengineering

Regulation and dynamics of force transmission at individual cell-matrix adhesion bonds

S. J. Tan, A. C. Chang, C. M. Miller, S. M. Anderson, L. S. Prahl, D. J. Odde, A. R. Dunn

The paper uses fluorescent molecular tension sensors to study force transmission by integrins in living cells, revealing functional modularity and a revised model for mechanical homeostasis.

bioRxiv · Jan 27, 2019Cell Biology

Glioma cell migration in confined microchannels via a motor-clutch mechanism

L. S. Prahl, M. R. Stanslaski, P. Vargas, M. Piel, D. J. Odde

This study investigates glioma cell migration in confined microchannels using a motor-clutch mechanism, showing that parameters from 2D experiments predict 1D migration behaviors.

bioRxiv · Dec 29, 2018Biophysics