The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults
A. Y. Nakhe, P. K. Dadi, J. Kim, M. T. Dickerson, S. Behera, J. R. Dobson, S. Shrestha, J.-P. Cartailler, L. Sampson, M. A. Magnuson, D. A. Jacobson
This study shows that the KCNK16 L114P mutation causes neonatal diabetes and glucose dyshomeostasis in adult mice by disrupting islet insulin secretion and increasing glucagon secretion.
bioRxiv · Jun 20, 2023 · PreprintPhysiology