Author

L. Savariau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. V. Lee· 3 shared J. M. Atkinson· 3 shared S. Oesterreich· 3 shared A. Elangovan· 2 shared F. Chen· 2 shared J. Hooda· 2 shared A. Kashiparekh· 1 shared A. Wedn· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

A. V. Lee

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Author profile →

3 papers

Recent·Most cited

Multi-omic characterization of ILC and ILC-like cell lines as part of ILC cell line encyclopedia (ICLE) defines new models to study potential biomarkers and explore therapeutic opportunities

O. S. Shah, F. Chen, A. Wedn, A. Kashiparekh, L. Savariau, B. Clifford, J. Hooda, M. Christgen, J. M. Atkinson, S. Oesterreich, A. V. Lee

The paper characterizes ILC and ILC-like cell lines through multi-omic analysis to identify molecular similarities with patient tumors and potential therapeutic targets.

bioRxiv · Sep 26, 2023 · PreprintCancer Biology

Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma

A. Elangovan, J. Hooda, L. Savariau, S. Puthanmadhomnarayanan, M. E. Yates, J. Chen, D. D. Brown, P. F. McAuliffe, S. Oesterreich, J. M. Atkinson, A. V. Lee

This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.

bioRxiv · Feb 22, 2022 · PreprintCancer Biology

Single cell transcriptomic heterogeneity in invasive ductal and lobular breast cancer cells

F. Chen, K. Ding, N. Priedigkeit, A. Elangovan, K. M. Levine, N. Carleton, L. Savariau, J. M. Atkinson, S. Oesterreich, A. V. LEE

The paper uses single-cell RNA sequencing to compare transcriptional heterogeneity between invasive ductal and lobular breast cancer cell lines, identifying CDH1 loss effects and potential mediators of ILC-specific features.

bioRxiv · Feb 21, 2020Cancer Biology