Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma
A. Elangovan, J. Hooda, L. Savariau, S. Puthanmadhomnarayanan, M. E. Yates, J. Chen, D. D. Brown, P. F. McAuliffe, S. Oesterreich, J. M. Atkinson, A. V. Lee
This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.
bioRxiv · Feb 22, 2022 · PreprintCancer Biology