Author

D. D. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. V. LEE· 3 shared M. E. Yates· 2 shared S. Oesterreich· 2 shared A. Alp· 1 shared A. C. Straub· 1 shared A. Casey· 1 shared A. Elangovan· 1 shared A. Fagunloye· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

A. V. LEE

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

L. Hong, d. C. Braden, Y. Zhao, J. J. Skoko, F. Chang, S. R. Woodcock, C. Uvale, A. Casey, K. Wood, S. Salavatore, A. Alp, T. Harkness, A. Fagunloye, M. Razzaghi, A. C. Straub, , C. A. Carola

This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.

bioRxiv · Aug 11, 2023Pharmacology & Toxicology

EstroGene database reveals diverse temporal, context-dependent and directional estrogen receptor regulomes in breast cancer

Z. Li, T. Li, M. E. Yates, Y. Wu, A. Ferber, L. Chen, D. D. Brown, J. Carroll, M. J. Sikora, G. Tseng, S. Oesterreich, A. V. LEE

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.

bioRxiv · Jan 30, 2023 · PreprintCancer Biology

Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma

A. Elangovan, J. Hooda, L. Savariau, S. Puthanmadhomnarayanan, M. E. Yates, J. Chen, D. D. Brown, P. F. McAuliffe, S. Oesterreich, J. M. Atkinson, A. V. Lee

This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.

bioRxiv · Feb 22, 2022 · PreprintCancer Biology