Author

P. F. McAuliffe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. M. Atkinson· 3 shared S. Oesterreich· 3 shared A. Elangovan· 2 shared A. V. Lee· 2 shared J. Hooda· 2 shared O. S. Shah· 2 shared P. C. Lucas· 2 shared A. Basudan· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

J. M. Atkinson

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4 papers

Recent·Most cited

WCRC-25: A novel luminal Invasive Lobular Carcinoma cell line model

A. Elangovan, E. A. Bossart, A. Basudan, N. Tasdemir, O. S. Shah, K. Ding, S. C. Purdy, C. Meier, T. Heim, C. Neumann, S. Attaran, L. Brown, J. Hooda, L. Miller, K. Kota, , S. Oesterreich

The paper introduces a new invasive lobular carcinoma cell line, WCRC-25, and demonstrates its molecular features and therapeutic response to PI3K/AKT inhibition.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

O. S. Shah, A. Nasrazadani, J. Foldi, J. M. Atkinson, C. G. Kleer, P. F. McAuliffe, T. J. Johnston, W. Stallaert, E. M. Da Silva, P. Selenica, H. Dopeso, F. Pareja, D. Mandelker, B. Weigelt, J. S. Reis-Filho, , S. Oesterreich

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

bioRxiv · Sep 9, 2023Cancer Biology

Loss of E-cadherin Induces IGF1R Activation Revealing a Targetable Pathway in Invasive Lobular Breast Carcinoma

A. Elangovan, J. Hooda, L. Savariau, S. Puthanmadhomnarayanan, M. E. Yates, J. Chen, D. D. Brown, P. F. McAuliffe, S. Oesterreich, J. M. Atkinson, A. V. Lee

This study shows that loss of E-cadherin in ILC leads to increased IGF1R activation and sensitivity to inhibitors, suggesting a therapeutic target and biomarker for ILC.

bioRxiv · Feb 22, 2022 · PreprintCancer Biology

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

S. H. Strand, B. Rivero-Gutierrez, K. E. Houlahan, J. A. Seoane, L. M. King, T. Risom, L. A. Simpson, S. Vennam, A. Khan, L. Cisneros, T. Hardman, B. Harmon, F. Couch, K. Gallagher, M. Kilgore, , K Owzar

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

bioRxiv · Jun 16, 2021 · PreprintCancer Biology