Author

L. Savary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Cavigliasso· 3 shared H. Gallart-Ayala· 3 shared J. Ivanisevic· 3 shared T. J. Kawecki· 3 shared B. Erkosar· 2 shared A. Casimiro-Garcia· 1 shared A. Koval· 1 shared B. G. Johnson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

F. Cavigliasso

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic adaptation to malnutrition in Drosophila

F. Cavigliasso, M. Savitskiy, A. Koval, B. Erkosar, L. Savary, H. Gallart-Ayala, J. Ivanisevic, V. L. Katanaev, T. J. Kawecki

This study identifies a cis-regulatory polymorphism in fiz that contributes to polygenic adaptation to malnutrition in Drosophila melanogaster by modulating ecdysone oxidase activity and larval growth.

bioRxiv · Aug 28, 2023 · PreprintEvolutionary Biology

Experimental evolution of metabolism under nutrient restriction: enhanced amino acid catabolism and a key role of branched-chain amino acids

F. Cavigliasso, L. Savary, J. Spangenberg, H. Gallart-Ayala, J. Ivanisevic, T. J. Kawecki

This paper shows that Drosophila melanogaster populations adapted to nutrient-poor diets evolved enhanced amino acid catabolism and a trade-off between amino acid use for energy and protein synthesis.

bioRxiv · Feb 6, 2023Evolutionary Biology

Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness in Drosophila

B. Erkosar, C. Dupuis, F. Cavigliasso, L. Savary, H. Gallart-Ayala, J. Ivanisevic, T. J. Kawecki

This study shows that evolutionary adaptation to juvenile malnutrition in Drosophila leads to metabolic changes in adults that impair fitness, suggesting non-independent evolution of juvenile and adult metabolism.

bioRxiv · Jan 11, 2022Evolutionary Biology

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

J. Wang, A. Casimiro-Garcia, B. G. Johnson, J. Duffen, M. Cain, L. Savary, S. Wang, P. Nambiar, M. Lech, S. Zhao, L. Xi, Y. Zhan, J. Olson, J. A. Stejskal, H. Lin, , K. Dower

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

bioRxiv · Dec 2, 2020 · PreprintPharmacology & Toxicology