Author

L. Spraggon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

M. Ladanyi· 2 shared A. A. Jungbluth· 1 shared A. B. Hartono· 1 shared A. D. Jayaprakash· 1 shared A. J. W. Lui· 1 shared C. A. Pratilas· 1 shared C. M. Lovly· 1 shared E. de Stanchina· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. Ladanyi

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach

R. S. Smith, I. Odintsov, Z. Liu, T. Hayashi, A. J. W. Lui, M. Vojnic, Y. Suehara, M. S. Mattar, J. Hmeljak, H. A. Ramirez, M. Shaw, G. Bui, A. B. Hartono, E. Gladstone, H. Magnan, , R. Somwar

This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.

bioRxiv · Sep 22, 2020 · PreprintCancer Biology

YES1 amplification: a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics

P.-D. Fan, G. Narzisi, A. D. Jayaprakash, E. Venturini, N. Robine, P. Smibert, S. Germer, H. A. Yu, E. J. Jordan, P. K. Paik, Y. Y. Janjigian, J. E. Chaft, L. Wang, A. A. Jungbluth, S. Middha, , M. Ladanyi

This study identifies YES1 amplification as a novel mechanism of resistance to EGFR inhibitors in lung cancer using transposon mutagenesis and clinical genomic analysis.

bioRxiv · Mar 17, 2018Cancer Biology