T. Hayashi

Intraplacental injection of human iPSC-derived PDX1+ pancreatic progenitors prolongs Pdx1-deficient mice survival

This study transplants human iPSC-derived pancreatic progenitors into Pdx1-deficient mice, extending their lifespan and demonstrating functional engraftment of human pancreatic cells.

Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites

This study uses NMR to show that GRB2's SH3 domains bind PRMs with different affinities and that phosphorylated EGFR binding affects GRB2's structure and domain interactions.

Effect of phage variation on Shiga toxin 2 (Stx2) production and the virulence of Stx-producing Escherichia coli

This study examines how variations in Stx2 phages affect Stx2 production and virulence in O145:H28 STEC strains, revealing differences in production levels based on phage type and repressor type.

Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation

The paper identifies Dusp13 and Dusp27 as MYOD target genes that regulate muscle stem cell transition from proliferation to differentiation during myogenesis.

5,6-dimethylxanthenone-4-acetic acid (DMXAA), a Partial STING Agonist, Competes for Human STING Activation

This paper investigates DMXAA's partial STING agonist activity and develops HHMX, a derivative that antagonizes STING-mediated immune responses in both humans and mice.

A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

This paper introduces a method to convert bacterial pathogens into live vaccines using unnatural amino acid-auxotrophic suicide derivatives, showing enhanced immunogenicity and safety.

Inhibitory effect of Ephedra herba on human norovirus infection in human intestinal organoids

This study screens Kampo crude drugs for anti-HuNoV effects using human intestinal organoids, identifying Ephedra herba as a novel inhibitor targeting the post-entry step of infection.

Identification of "missing links" in C- and D-ring cleavage of steroids by Comamonas testosteroni TA441

This paper identifies missing intermediates in the C- and D-ring cleavage of steroids by Comamonas testosteroni TA441, completing the degradation pathway.

Comprehensive summary of steroid metabolism in Comamonas testosteroni TA441; entire degradation process of basic four rings and removal of C12 hydroxyl group

The paper identifies and functionally characterizes genes involved in the removal of the C12 hydroxyl group in steroids by Comamonas testosteroni TA441, completing the pathway for steroid ring degradation.

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model.

Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance

The paper shows that glutamine synthetase mRNA produces an sRNA, GlnZ, which regulates carbon/nitrogen metabolism by repressing SucA expression.

Evolutionary relations between mycorrhizal symbiosis and plant-plant communication in trees

The paper investigates the link between mycorrhizal symbiosis types and plant-plant communication in trees, finding that ECM promotes communication among conspecifics.

Spontaneous myocarditis in mice predisposed to autoimmune disease: Including Vaccination-induced onset

This study shows that reduced NF-κB1 expression in NOD/ShiLtJ mice leads to severe myocarditis and insulitis, and vaccination can trigger myocarditis in these mice.

Evaluation of heat inactivation of human norovirus in freshwater clams using human intestinal enteroids

This study evaluates heat inactivation of human norovirus in freshwater clams using human intestinal enteroids, finding that 1 minute at 90°C inactivates the virus.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

LIFELONG CYTOMEGALOVIRUS AND EARLY-LIFE IRRADIATION SYNERGISTICALLY POTENTIATE AGE-RELATED DEFECTS IN RESPONSE TO VACCINATION AND INFECTION

This study shows that lifelong cytomegalovirus and early-life irradiation together worsen age-related immune defects in response to vaccination and infection.

Dasabuvir inhibits human norovirus infection in human intestinal enteroids

This study identifies dasabuvir as an anti-HuNoV inhibitor using human intestinal enteroids, showing activity against HuNoV, SARS-CoV-2, and RVA.

Identification of the CoA-ester intermediates and genes involved in the cleavage and degradation of the steroidal C-ring by Comamonas testosteroni TA441

Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

This study identifies a bi-phasic effect of gelatin on skeletal muscle regeneration through ROS-mediated signaling, showing low-dose gelatin promotes regeneration while high-dose inhibits it.

The 3' end of the human norovirus antigenomic sequence is required for its genomic RNA synthesis by RNA-dependent RNA polymerase

This study identifies the 3' end stem-loop structure of the human norovirus antigenomic sequence as essential for RdRp-mediated genomic RNA synthesis.

Identification of essential β-oxidation genes and corresponding metabolites for estrogen degradation by actinobacteria

This study identifies essential β-oxidation genes and metabolites involved in estrogen degradation by actinobacteria using transcriptomics, gene disruption, and metabolite profiling.

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population

This study identifies the distribution and functionality of the pks island in E. coli strains, showing its presence across multiple phylogroups and its role in colibactin production.

Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory amino acid differences and novel oncoprotein candidates

This study uses GWAS to identify genetic variations in H. pylori strains associated with gastric cancer and duodenal ulcers, revealing amino acid differences and novel oncoprotein candidates.

Effect of RBD mutation (Y453F) in spike glycoprotein of SARS-CoV-2 on neutralizing antibody affinity

This study examines how the Y453F mutation in the SARS-CoV-2 spike protein affects neutralizing antibody affinity, showing partial escape from four monoclonal antibodies.

Impact of COVID-19: Decrease in the Number of Fledging Barn Swallow Chicks in Tokyo

The paper investigates the link between reduced human activity during the COVID-19 pandemic and decreased fledging of barn swallow chicks in Tokyo.

Genetic and metabolite biomarkers reveal actinobacteria-mediated estrogen biodegradation in urban estuarine sediment

This study identifies actinobacterial genes and metabolites involved in estrogen degradation in urban estuarine sediments and finds actinobacteria, not proteobacteria, are primarily responsible for estrogen breakdown.

Adhesion to type I collagen fibrous gels induces E- to N- cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549

This study shows that A549 lung cancer cells cultured on type I collagen gels switch from E-cadherin to N-cadherin without other epithelial-mesenchymal transition features.

Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach

This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.

Diversification of the restriction modification system of Streptococcus pyogenes through its acquisition of mobile elements

The paper analyzes methyltransferase diversity in Streptococcus pyogenes by comparing RM systems across genomes and suggests phage-derived MTases contribute to methylome diversity and gene regulation.

Personality, Subjective Well-Being, and the Serotonin 1a Receptor Gene in Common Marmosets (Callithrix jacchus)

The study examines personality traits in common marmosets, identifying multiple factors and their relationship with well-being, but finds no genetic associations.