C. A. Pratilas

MEK inhibition enhances the antitumor effect of radiation therapy in NF1-deficient glioblastoma

This study shows that combining MEK inhibition with radiation therapy enhances antitumor effects in NF1-deficient glioblastoma models.

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors

This study shows that combining SHP2 inhibitor TNO155 with CDK4/6 inhibitor enhances anti-tumor activity in MPNST by restoring RB function and overcoming resistance.

Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors

This study shows that combining NF1 and ATRX deficiency makes certain solid tumors vulnerable to ATR inhibition, especially those with alternative lengthening of telomeres.

Establishment of multiple novel patient-derived models of desmoplastic small round cell tumor enabling functional characterization of ERBB pathway signaling and pre-clinical evaluation of a novel targeted therapy approach

This study develops new DSRCT models and shows that targeting the ERBB pathway with EGFR inhibitors reduces tumor growth in preclinical models.

A clinically and genomically annotated nerve sheath tumor biospecimen repository.

The paper establishes a clinically and genomically annotated nerve sheath tumor biospecimen repository to support research on NF1-related tumors.