Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth.
M. K. Penny, A. M. Lerario, K. J. Basham, S. Chukkapalli, Y. Yu, D. R. Mohan, C. LaPensee, K. Converso-Baran, M. Hoenerhoff, L. Suarez Fernandez, C. Gonzalez del Rey, T. J. Giordano, R. Han, E. A. Newman, G. D. Hammer
This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.
bioRxiv · Oct 23, 2022Cancer Biology