Author

R. Han

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 2 Bioengineering· 1 Biophysics· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. Li· 3 shared J. Ma· 3 shared B. Li· 2 shared J. Zhong· 2 shared L. Sheng· 2 shared N. Zheng· 2 shared W. Jia· 2 shared Y. Gu· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

H. Li

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience

S. Cheng, C. Feng, L. U. Wingen, H. Cheng, A. B. Riche, M. Jiang, M. Leverington-Waite, Z. Huang, S. Collier, S. Orford, X. Wang, R. Awal, G. Barker, T. O'Hara, C. Lister, , K

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

bioRxiv · Oct 4, 2023 · PreprintPlant Biology

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

Y. Hong, N. Zheng, X. He, J. Zhong, J. Ma, A. Zhao, X. Zheng, Y. Gu, J. Yao, Y. Li, L. Yuan, M. Lin, X. Lu, J. Ping, P. Song, , H. Li

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

bioRxiv · Nov 21, 2022Physiology

Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth.

M. K. Penny, A. M. Lerario, K. J. Basham, S. Chukkapalli, Y. Yu, D. R. Mohan, C. LaPensee, K. Converso-Baran, M. Hoenerhoff, L. Suarez Fernandez, C. Gonzalez del Rey, T. J. Giordano, R. Han, E. A. Newman, G. D. Hammer

This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.

bioRxiv · Oct 23, 2022Cancer Biology

IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits

t. koike, y. koike, y. guo, d. yang, j. song, j. xu, x. zhao, t. zhu, r. li, b. wen, D. Sun, o. rom, R. Han, j. fan, m. t. Garcia-Barrio, , y. e. chen

This study shows that IDOL deficiency reduces atherosclerosis in rabbits fed a high-cholesterol diet by improving lipid metabolism and bile acid excretion.

bioRxiv · May 3, 2022Physiology

Stereo-specific Lasofoxifene Derivatives Reveal the Interplay between Estrogen Receptor Alpha Stability and Antagonistic Activity in ESR1 Mutant Breast Cancer Cells

D. J. Hosfield, S. Weber, N.-S. Li, M. Suavage, E. Sullivan, E. Nduwke, R. Han, S. Cush, M. Laine, S. C. Mader, G. L. Greene, S. W. Fanning

The paper synthesizes lasofoxifene derivatives to study how ER cellular lifetime and antagonistic activity relate in ESR1 mutant breast cancer cells, finding that reducing ER lifetime does not always enhance transcriptional antagonism.

bioRxiv · Aug 27, 2021Cancer Biology

Structural basis for the dimerization-dependent CRISPR-Cas12f nuclease

L. Chang, R. Xiao, Z. Li, S. Wang, R. Han

This study determines the cryo-EM structures of Cas12f to elucidate its dimerization-dependent mechanism for DNA cleavage and substrate recognition.

bioRxiv · Dec 22, 2020 · PreprintBiophysics

Efficient precise in vivo base editing in adult dystrophic mice

L. Xu, C. Zhang, H. Li, P. Wang, Y. Gao, P. J. Mohler, N. Mokadam, J. Ma, W. D. Arnold, R. Han

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

bioRxiv · Jun 24, 2020Bioengineering

Angioplasty-induced epigenomic remodeling entails BRD4 and EZH2 hierarchical regulations

M. Zhang, B. Wang, G. Urabe, G. Ozer, R. Han, C. Kent, L. Guo

This study investigates how angioplasty induces epigenomic changes in rats, revealing BRD4 and EZH2's roles in regulating neointimal hyperplasia through histone modifications.

bioRxiv · Mar 12, 2020 · PreprintPathology

Variations of gut microbiome profile under different storage conditions and preservation periods: A multi-dimensional evaluation

J. Ma, L. Sheng, C. Xi, Y. Gu, Y. Hong, N. zheng, L. Chen, G. Wu, Y. Li, J. Yan, R. Han, B. Li, H. Qiu, J. Zhong, W. Jia, H. Li

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

bioRxiv · Aug 31, 2019Microbiology